How does magnesium oxide affect the stability of drugs?

Magnesium oxide(MgO)is a commonly used stabilizer that can be used to increase the stability of drugs.It can form a protective layer of magnesium oxide around drug molecules,thereby slowing down the rate of drug decomposition.Here are some ways in which magnesium oxide affects drug stability:

Magnesium oxide(MgO)is a commonly used stabilizer that can be used to increase the stability of drugs.It can form a protective layer of magnesium oxide around drug molecules,thereby slowing down the rate of drug decomposition.Here are some ways in which magnesium oxide affects drug stability:

Alkalinization effect:Magnesium oxide has a certain alkalinity,which can neutralize the acidic components in drugs,thereby reducing the rate of drug decomposition.For example,in antibiotics,magnesium oxide can prevent the toxic effects of acidic substances produced by drug decomposition on microorganisms.

Complexation:Magnesium oxide can form complexes with metal ions or other compounds in drug molecules,thereby slowing down the rate of drug decomposition.For example,in some anti-tumor drugs,magnesium oxide can form complexes with platinum ions,thereby improving the stability and efficacy of the drugs.

Sustained release effect:Magnesium oxide has a certain sustained-release effect and can be used as a drug release control agent.For example,among the drugs for treating diabetes,magnesium oxide can slow down the release rate of drugs in the gastrointestinal tract,thus reducing the fluctuation of blood sugar concentration.This helps to maintain the effectiveness of the medication and reduce the occurrence of side effects.

It should be noted that although magnesium oxide can improve the stability of drugs,excessive use may lead to adverse reactions or other problems.Therefore,when using magnesium oxide as a stabilizer,it is necessary to control and monitor the dosage reasonably according to the specific situation.