In general, domestic allowable travel costs both for government travelers and for grantees is that found at http://www.gsa.gov/perdiem. If there no hotels available at per diem then if your organization has an "acceptable" written travel policy then that seems to allow you to charge those costs to the grant even though they are in excess of the normal per diem. I confess that I don't know what makes an organization's written travel policy "acceptable", but NASA can authorize the extra expense, see the GSA per diem FAQ #18. I have done this on more than one occasion.
When traveling outside of the USA grantees are generally subject to the Fly America Act, which requires grantees to use U.S. Airlines when they are available. However, our grantees, always eager to stretch their dollar often want to use a local carrier if it's cheaper. It turns out that thanks to our "Open Skies Agreements" our grantees may fly on foreign airlines if the cost is the same or less, when flying to or within certain countries. At the time of the writing of this FAQ these agreements cover the EU, Switzerland, Australia, and Japan. For more information and the latest updates please see http://www.gsa.gov/portal/content/. Remember, if you are planning to travel outside of the USA and the trip was not in your original proposal, concurrence from NASA is required. Yes, travel to Canada and Mexico are considered "foreign" travel.
Finally, some grantees are aware that NASA civil servants with whom they work have a special limit on days off associated with work travel. The NASA civil servants may not take off more days than they are working, i.e., if they fly to Europe for a mission team meeting that lasts three days, they can add at most three days of vacation, even if it were to decrease the cost of the ticket. This rule does not apply to researchers on NASA Grants. This aspect of grantee travel is governed by their organization's travel policy.
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