This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
For more information, please visit larocaine powder.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Catalog No. T7118 CAS 94-15-5
Synonyms: Larocaine
Dimethocaine (Larocaine) is a local anesthetic which also effects on the central nervous system acting as dopamine-reuptake-inhibitor.
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Dimethocaine, CAS 94-15-5
Pack Size Availability Price/USD Quantity 100 mg In stock $ 74.00 200 mg In stock $ 98.00 500 mg In stock $ 148.00 Bulk InquiryGet quote
Select Batch
Purity
:98%
Contact us for more batch information
Biological Description
Chemical Properties
Storage
& SolubilityInformation
Description Dimethocaine (Larocaine) is a local anesthetic which also effects on the central nervous system acting as dopamine-reuptake-inhibitor. Synonyms Larocaine Molecular Weight 278.39 Formula C16H26N2O2 CAS No. 94-15-5
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (179.6 mM)
This product is contained In the following compound libraries：
Related compounds with same targets
You can also refer to dose conversion for different animals. More
Step One: Enter information below
Dosage
mg/kgAverage weight of animals
gDosing volume per animal
ulNumber of animals
Step Two: Enter the in vivo formulation
% DMSO+
% +
% Tween 80+
% ddH2O
%DMSO+
%
Calculate ResetCalculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL Corn oil，mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
Mass
Contact us to discuss your requirements of Phenacetin cas 62-44-2. Our experienced sales team can help you identify the options that best suit your needs.
=
Concentration
X
Volume
X
Molecular Weight
See Example
An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box
Concentration (Start)
X
Volume (Start)
=
Concentration (End)
X
Volume (End)
Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.
See Example
An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box
Volume (to add to vial)
=
Mass (in vial)
/
Desired Reconstitution Concentration
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Molecule Formula
Molecular Weight g/mol
Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Dimethocaine 94-15-5 GPCR/G Protein Neuroscience Others Dopamine Receptor Inhibitor Larocaine inhibit inhibitor
Dimethocaine (DMC, larocaine, 3-diethylamino-2,2-dimethylpropyl)-4-aminobenzoate) was marketed as local anesthetic in the 1930s and used in dentistry and ophthalmology.[1]It is a synthetic product, is the p-aminobenzoyl ester of 2,2-dimethyl-3-diethylamino-1-propanol. It is supplied in the form of a hydrochloride, a white cryst. powder sol. in water up to 50%. Chemically it is related to procaine-HCl and tutocaine.[2]
Besides local anesthetic effects, dimethocaine has also effects on the central nervous system acting as dopamine-reuptake-inhibitor. It is listed by the EMCDDA under the category “synthetic cocaine derivatives”.The abuse is described to produce feelings of euphoria and sometimes relaxed feeling accompanied with side effect such as a strong hangover and fatigue. Dimethocaine was shown to have high affinity for the dopamine transporter mainly in the nucleus accumbens stimulating the reward system. Furthermore, the previous litertaures have shown that dimethocaineis nearly as potent as cocaine concerning the dopamine-reuptake-inhibitor efficiency.Dimethocaine, a synthetic derivative of cocaine, is distributed and consumed as “new psychoactive substance” (NPS).It is mainly metabolized by N-acetylation, N-deethylation or hydroxylation.The endogenous N-acetylation as main part of dimethocaine metabolism was catalyzed by the NAT2 isozyme.[1]
Figure 1 Dimethocaine powder
The dimethocaine has cocaine-like effects. For example, dimethocaine was found to be nearly as potent as cocaine in blocking dopamine uptake in striatal synaptosomes and that it competed for binding to the transporter. Also, as mentioned previously, dimethocaine was shown to be consistently self-administered at a high rate by monkeys and to substitute fully for cocaine in rats and monkeys trained to discriminate cocaine from vehicle. What’s more, dimethocaine has also been shown to induce rotational behavior in substantia nigra-lesioned rats. The present findings showing a stimulant-like profile of dimethocaine are in agreement with the notion that the reinforcing and the activating effects of psychostimulants are mediated by a common mechanism.[4]In addition, dimethocaine, local anesthetics of amide and ester classes, respectively, showed effective antinociceptive responses in all tests at nontoxic doses and these responses are mediated, at least in part, by their central actions.[5]
On the one hand, as expected for a central nervous system (CNS) stimulant, dimethocaine acts mainly as a dopaminereuptake-inhibitor. Like cocaine, dimethocaine is snorted since oral ingestion would lead to rapid hydrolysis of dimethocaine.On the other hand,dimethocaine is similar potent as cocaine concerning the DA-reuptake-inhibitor efficiency, and it has high affinity for the DA transporter mainly in the nucleus accumbens stimulating the reward system.[3]
Initial activity screening revealed that only NAT2 was capable catalyzing the N-acetylation of dimethocaine. Besides the extensive N-acetylation of the p-aminobenzoic acid part of the parent compound, most of the phase I metabolites were excreted as N-acetyl derivatives.It is obvious that there might be individual pharmacokinetic differences of the endogenous N-acetylation of dimethocaine, which may lead to increased negative side effects such as cardiotoxicity. Such interactions may be much more important for people with a slow acetylation phenotype. To what extent these points affect the plasma concentrations of dimethocaine and also the concentration of acetylated dimethocaine metabolites in urine.the presented metabolism study demonstrated the extensive metabolism of dimethocaine by the rat mainly via hydroxylation and deethylation as well as acetylation and glucuronidation. The endogenous N-acetylation as main part of dimethocaine metabolism was catalyzed only by the NAT2 isozyme. [3]
After consumption of dimethocaine, consumers describe feelings of euphoria but also dyspnea and complaints of angina pectoris. The intravenous abuse is described to produce an initial flush and an alert or sometimes even relaxed feeling in the first minutes after injection accompanied with side effect such as a strong hangover and fatigue.So, it is careful for its usage.[3]
[1]Meyer MR,et.al. Dimethocaine, a synthetic cocaine derivative: studies on its in vitro metabolism catalyzed by P450s and NAT2[J]. Toxicology Letters. 2014, 225(1): 139-146.
[2]LEO L,MAYER MD.LAROCAINE, A NEW ANESTHETIC[J]. Archives of Ophthalmology, 1935, 14(3): 408-411.
[3]Lindauer C. Toxicokinetics of Emerging Drugs of Abuse: In vivo and in vitro studies on the metabolic fate of the cocaine-derived designer drug dimethocaine[J]. 2014.
[4]Rigon, AR., Takahashi, RN.Stimulant activities of dimethocaine in mice: reinforcing and anxiogenic effects[J].Psychopharmacology. 1996,127:323-327.
[5]Rigon AR, Takahashi RN. The effects of systemic procaine, lidocaine and dimethocaine on nociception in mice[J]. General pharmacology, 1996, 27(4): 647-650.
The company is the world’s best Lidocaine HCl cas 73-78-9 supplier. We are your one-stop shop for all needs. Our staff are highly-specialized and will help you find the product you need.