Chloroacetyl chloride | CAS#:79-04-9

23 Sep.,2024

 

Chloroacetyl chloride | CAS#:79-04-9

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AO
CHEMICAL NAME :
Acetyl chloride, chloro-
CAS REGISTRY NUMBER :
79-04-9
BEILSTEIN REFERENCE NO. :
LAST UPDATED :
DATA ITEMS CITED :
27
MOLECULAR FORMULA :
C2-H2-Cl2-O
MOLECULAR WEIGHT :
112.94
WISWESSER LINE NOTATION :
GV1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
208 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., Volume(issue)/page/year: 5,123(89),
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., Volume(issue)/page/year: -,607,
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
662 mg/kg
TOXIC EFFECTS :
Skin and Appendages - corrosive (after topical exposure)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, Moscow, USSR) V.1- - Volume(issue)/page/year: 54(2),90,
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, Moscow, USSR) V.1- - Volume(issue)/page/year: 54(2),90,
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
ppm/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., Volume(issue)/page/year: 5,123(89),
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD ) Volume(issue)/page/year: NX#
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., Volume(issue)/page/year: 5,123(89), ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 ppm/6H/4W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA ) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 ppm/6H/4W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA ) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
5 ppm/6H/4W-I
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA ) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS *** REVIEWS *** ACGIH TLV-STEL 0.69 mg/m3 (0.15 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, Volume(issue)/page/year: TLV/BEI, ACGIH TLV-TWA 0.23 mg/m3 (0.05 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, Volume(issue)/page/year: TLV/BEI, *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.05 ppm (0.2 mg/m3) JAN OEL-BELGIUM:TWA 0.05 ppm (0.23 mg/m3) JAN OEL-DENMARK:TWA 0.05 ppm (0.2 mg/m3) JAN OEL-FRANCE:TWA 0.05 ppm (0.2 mg/m3) JAN OEL-THE NETHERLANDS:TWA 0.05 ppm (0.2 mg/m3) JAN OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN OEL-SWITZERLAND:TWA 0.05 ppm (0.24 mg/m3) JAN OEL-UNITED KINGDOM:TWA 0.05 ppm (0.2 mg/m3) JAN OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHLOROACETYL CHLORIDE-air:10H TWA 0.05 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100, NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey () NOHS Hazard Code - A No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 66 (estimated) NOES - National Occupational Exposure Survey () NOES Hazard Code - A No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: (estimated) No. of Female Employees: 729 (estimated)

Chloroacetyl Chloride CAS 79-04-9

Product Description

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About Chloroacetyl Chloride CAS 79-04-9

CAS 79-04-9 refers to the chemical compound ethylene glycol, also known as 1,2-ethanediol. It is a colorless, odorless, and sweet-tasting liquid that is commonly used as a coolant and antifreeze in various industrial and consumer applications, including automotive engines, HVAC systems, and refrigeration equipment. However, ethylene glycol is highly toxic if ingested, and can cause serious health problems or even death if not treated promptly. Therefore, it should be handled with caution and stored properly to prevent accidental exposure.

Product Name: Chloroacetyl Chloride

Synonyms:

CAC

CACL

Monochloroacetyl chloride

2-Chloroacetyl chloride

Chloroacetic acid chloride

Chloroacetic chloride

Monochloroacetyl chloride

 

CAS: 79-04-9

Molecular Formula: C2H2Cl2O

Chloroacetyl Chloride Molecular Weight: 112.94

Molecular Structure:

 

Property:

Vapor Pressure: 19 mm Hg

Specific Gravity: 1.42 at 68 ° F

Chloroacetyl Chloride Boiling Point Boiling Point: 221 ° F at 760 mm Hg

Chloroacetyl chloride molecular weight: 112.9

Water Solubility: Decomposes

 

Specification:

Appearance

Colorless to light yellow liquid

Specific Gravity

1.208-1.222g/cm3

If you want to learn more, please visit our website 2,2'-Dichlorodiethyl ether.

Purity

&#;99%

Dichloroacetyl chloride

&#;0.5%

Individual unknown impurity

&#;0.5%

 

Application:

The major use of chloroacetyl chloride is as an intermediate in the production of herbicides in the chloroacetanilide family including metolachlor, acetochlor, alachlor and butachlor; an estimated 100 million pounds are used annually. Some chloroacetyl chloride is also used to produce phenacyl chloride, another chemical intermediate, also used as a tear gas.[3] Phenacyl chloride is synthesized in a Friedel-Crafts acylation of benzene, with an aluminium chloride catalyst:[6]

 

With anisole, it is used for the synthesis of venlafaxine.

 

Package:

This product is packed in 200litre drums. The net weight of each drum is or 280 kg/drum.

 

 

Storage:

Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat/sparks/open flames/ hot surfaces. Store away from incompatible materials and foodstuff containers.

Chloroacetyl Chloride CAS 79-04-9 Safety & Regulations

 

Chloroacetyl chloride is a hazardous chemical that can cause severe burns and irritation to the skin, eyes, and respiratory system. As such, it is important to handle it with caution and follow all necessary safety precautions. Here are some key safety and regulatory considerations for Chloroacetyl Chloride:

  1. Personal protective equipment (PPE): When handling Chloroacetyl chloride, it is important to wear appropriate PPE, including gloves, goggles, and a respirator. This can help protect against inhalation or skin contact with the substance.

  2. Storage and handling: Chloroacetyl chloride should be stored in a cool, dry, well-ventilated area, away from sources of ignition or heat. It should be kept in tightly sealed containers and separated from incompatible substances.

  3. Transportation: Chloroacetyl chloride is regulated for transportation under various national and international regulations, including the UN Model Regulations on the Transport of Dangerous Goods. This may require special labeling, packaging, and documentation for shipment.

  4. Disposal: Chloroacetyl chloride waste should be disposed of in accordance with applicable regulations and guidelines, which may vary depending on the location and nature of the waste.

  5. Regulatory compliance: Chloroacetyl chloride is subject to various regulatory requirements, including registration and reporting under the Toxic Substances Control Act (TSCA) in the United States, and similar regulations in other countries. Manufacturers and users of Chloroacetyl chloride should ensure compliance with all applicable regulations.

In summary, Chloroacetyl chloride is a hazardous substance that requires careful handling and compliance with applicable regulations and guidelines to ensure the safety of workers and the environment. As a manufacturer or user of Chloroacetyl chloride, it is important to stay informed of current safety and regulatory requirements and take appropriate measures to minimize risks.