If you search "buy erectile dysfunction drugs" online, you'll bring up millions of websites selling well-known ED drugs for sale, as well as many "natural" remedies that promise to give you the same results.

The company is the world’s best order tadalafil supplier. We are your one-stop shop for all needs. Our staff are highly-specialized and will help you find the product you need.

Are they safe to buy? Experts say think twice before you purchase online.

Risks of Online ED Drugs

The ED drugs and herbal remedies you buy on the internet aren't always what they seem. An FDA investigation found that more than one-third of "dietary supplements" sold for ED actually contained prescription drugs, including sildenafil, the medicine in Viagra.

Some ED drugs sold online contained entirely different medicines, such as the antibiotic metronidazole and the fertility drug clomiphene.

Even if a drug contains the right medicine, it may not be the right dose. When samples of 100-milligram Viagra tablets purchased online were tested, only 10% were even close to the advertised strength.

When you buy from an unknown company, you run the risk of getting counterfeit medicines. By some estimates, more than half of all ED drugs sold online are fakes. Some of these drugs include ingredients you wouldn't want to put in your body -- things like talcum powder, paint, and printer ink.

The FDA warns of a number of products that have contained potentially harmful ingredients or compounds that aren't mentioned on the label. Among them are:

• 4EVERON
• Actra-Rx
• Actra-Sx
• Adam Free
• Blue Steel
• Energy Max
• Erextra
• Hero
• HS Joy of Love
• Lady Shangai
• Libidus
• Liviro3
• Lycium Barbarum L.
• Nasutra
• Naturalë Super Plus
• NaturalUp
• Neophase
• Rhino V Max
• Shangai Regular, also marketed as Shangai Chaojimengnan
• Shangai Ultra
• Shangai Ultra X
• Strong Testis
• Super Shangai
• True Man
• V.Max
• Vigor-25
• Xiadafil VIP tablets (Lots 6K029 and 6K209-SEI only)
• Yilishen
• Zimaxx

Health Concerns

Erectile dysfunction drugs that are approved by the FDA work by increasing blood flow to the penis. Just like any other medicine, these drugs can have side effects. If you purchase them online -- without a prescription -- you won't get a chance to discuss this with your doctor before you take them.

ED drugs can also be dangerous if you have certain conditions, like heart disease. They can interact with other medicines you take, such as blood thinners and some alpha blockers, which are used to treat high blood pressure and prostate conditions. Even mixing them with grapefruit juice can worsen side effects. These are issues your doctor needs to talk to you about during an office visit before they prescribe the medicine.

If you buy an "herbal remedy" online that turns out to contain ingredients from real ED drugs, you could also put your health at risk. For example, if sildenafil is hidden in natural ED treatments, you could run into trouble if you use nitrates for heart disease. The combo can lead to a dangerous drop in blood pressure.

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Tadalafil: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on Nov 20, .

1. How it works

• Tadalafil is a medication used to treat erectile dysfunction (ED) or symptoms of benign prostatic hypertrophy (BPH).
• Tadalafil blocks the action of an enzyme known as cGMP-specific phosphodiesterase type-5 (PDE-5). This enzyme breaks down cGMP, a substance that induces smooth muscles to relax. Blocking PDE-5 means increased levels of cGMP within the smooth muscles which promotes muscle relaxation and vasodilation (a widening of blood vessels).
• High levels of PDE-5 are found in the penis, lungs, and retina. PDE-5 is also found throughout the body within the smooth muscle cells of blood vessels and muscles.
• Tadalafil belongs to the class of medicines known as PDE-5 inhibitors.

2. Upsides

• Tadalafil is used for the treatment of erectile dysfunction (ED). It increases blood flow to the penis following sexual stimulation and allows men to keep an erection hard enough for sex.
• Tadalafil is also used to treat the signs and symptoms of benign prostatic hyperplasia (BPH).
• Tadalafil is available as a lower-strength tablet that can be taken daily, eliminating the need to 'plan' for sex.
• Tadalafil is also available as an 'as needed' tablet. The recommended starting dose is 10mg taken before sexual activity and the effects of one tablet lasts for up to 36 hours.
• The recommended starting dose for tadalafil intended for once-daily use for sexual activity is 2.5mg, taken at the same time each day, without regard to the timing of sexual activity. This may be increased to 5mg/day based on need and tolerability. When used to treat BPH, tadalafil should be started at 5mg daily.
• May be taken with or without food.
• Tadalafil is a generic, which means it is sold at a lower price compared to branded versions of tadalafil (such as Cialis).

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

• A headache, dyspepsia, back pain, nasal congestion, and flushing are the most commonly reported side effects.
• Other side effects include a drop in blood pressure, muscle or limb pain, or conjunctivitis.
• Rarely, may decrease blood flow to the optic nerve causing sudden vision loss. The risk is greater in people aged older than 50, with diabetes, heart disease, high blood pressure, high cholesterol, who smoke, or with certain pre-existing eye problems.
• Rarely, may cause other side effects including hearing loss, or lead to painful erections lasting longer than four to six hours. See your doctor immediately if this happens.
• May not be suitable for some people including those with angina, chest pain, other heart conditions, liver or kidney problems, blood or bleeding disorders, stomach ulcers, certain eye conditions, or a physical deformity of the penis (such as Peyronie's disease).
• May interact with some medications including nitrates - the use of tadalafil and nitrates is contraindicated because of the severe hypotension that can develop. May also interact with other medications including ketoconazole or ritonavir; dosage adjustment is recommended.
• The dosage of tadalafil may need to be reduced in men with kidney disease. Once-daily use may not be recommended in men with severe kidney disease.
• Only use for 26 weeks when given with finasteride to initiate BPH treatment, because the benefit of Tadalafil tablets decreases from 4 weeks until 26 weeks, and benefits beyond 26 weeks are unknown
• A lower dosage of tadalafil is recommended in men with mild-to-moderate liver disease. Tadalafil should be avoided with severe liver disease.
• Not for use in females.

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

• Tadalafil is used to treat erectile dysfunction (ED) or to reduce symptoms of benign prostatic hyperplasia (BPH). One 'as needed' tablet lasts for 36 hours or tadalafil is available as a lower dosage that can be taken daily, eliminating the need to 'plan for sex'. Tadalafil is a generic that costs less than branded versions.

5. Tips

• Once-daily Tadalafil can be taken without regard to sexual activity but should be taken at the same time every day (for example, on awakening).
• Tadalafil may be taken with or without food.
• Do not split tadalafil tablets. The entire dose should be taken.
• Drinking alcohol after taking tadalafil may lower blood pressure and decrease sexual performance.
• Eating grapefruit or grapefruit products while taking tadalafil is not recommended.
• Always talk to your doctor before taking ANY medication for ED. Some ED medications are not suitable for men with certain medical conditions.
• Call your doctor immediately if you experience dizziness, feel nauseous during sexual activity, or develop pain, numbness, or tingling in your chest, arms, neck, or jaw.
• Do not take tadalafil if you are also taking a nitrate drug (such as nitroglycerin or isosorbide dinitrate/mononitrate) for chest pain or heart problems. Do not take tadalafil with recreational drugs such as "poppers". Taking these substances together can cause a sudden and dangerous drop in blood pressure.
• Always buy your ED medications from a reputable supplier as there are a lot of counterfeit products in circulation.
• Certain lifestyle and psychological factors, such as smoking, drinking, and stress, can exacerbate ED. Eliminating these - for example, staying more active, losing weight if you are overweight, reducing alcohol intake, stopping smoking, and reducing stress - may also help improve ED.
• Taking tadalafil does not protect you from sexually transmitted diseases. Consider condom risk or abstinence if a sexual partner's history is unknown.
• Seek urgent medical advice if an allergic reaction, sudden vision loss, or painful erections lasting more than four hours occur.
• Viagra is not intended for women.

6. Response and effectiveness

• Peak plasma concentrations of tadalafil are reached within 30 minutes to six hours (average time two hours) of a dose. Effects of 'as needed' tadalafil last for up to 36 hours.
• The recommended starting dose for once-daily tadalafil for ED is 2.5mg; once-daily tadalafil for BPH: 5mg; and 'as needed' tadalafil: 10mg. The dosage may be adjusted based on individual response.

7. Interactions

Medicines that interact with tadalafil may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with tadalafil. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with tadalafil include:

• alpha-agonists (eg, clonidine, methyldopa)
• alpha-blockers (eg, alfuzosin, doxazosin, tamsulosin, or terazosin)
• antibiotics, such as clarithromycin, erythromycin, metronidazole, norfloxacin, rifabutin, rifampin, or tetracycline
• antidepressants, such as desipramine or sertraline
• antifungal medications, such as itraconazole, ketoconazole, or voriconazole
• cystic fibrosis medications, such as ivacaftor
• epilepsy medications, such as carbamazepine, oxcarbazepine, phenobarbital, phenytoin, or primidone
• erectile dysfunction medications (eg, alprostadil, Cialis, sildenafil, vardenafil)
• heart medications, such as amlodipine, amiodarone, atenolol, candesartan, captopril, clonidine, diltiazem, enalapril, irbesartan, losartan, nifedipine, propranolol, sotalol, or verapamil
• hepatitis medications, such as boceprevir and simeprevir
• HIV medications (eg, atazanavir, delavirdine, efavirenz, indinavir, etravirine, ritonavir, nevirapine, saquinavir, or tipranavir)
• nitrates (eg, amyl nitrate, isosorbide dinitrate, isosorbide mononitrate, or nitroglycerin)
• others, such as aprepitant, cyclosporine, or imatinib.

In addition, taking tadalafil with too much alcohol can lead to orthostatic hypotension, which is a drop in blood pressure when you go from a sitting or lying down position to standing. Symptoms include a headache, dizziness, or fainting when standing.

Antacids, such as magnesium hydroxide or aluminum hydroxide may also affect the absorption of tadalafil. Grapefruit juice may also increase the side effects of tadalafil.

Note that this list is not all-inclusive and includes only common medications that may interact with tadalafil. You should refer to the prescribing information for tadalafil for a complete list of interactions.

References

• Tadalafil. Updated 11/. NorthStar RxLLC. https://www.drugs.com/pro/tadalafil.html

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use tadalafil only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright - Drugs.com. Revision date: November 19, .

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